Sprague Dawley rats: A model of successful heart aging
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منابع مشابه
CYP3A Mediated Ketamine Metabolism is Severely Impaired in Liver S9 Fractions from Aging Sprague Dawley Rats
Ketamine is widely used in veterinary medicine and in medicine. Ketamine is metabolized to its active metabolite norketamine principally by liver CYP3A. Drug metabolism alterations during aging have severe consequences particularly in anesthesiology and very few studies on older animals were conducted for ketamine. The objective of the present study is to assess the influence of aging on CYP3A ...
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Male Sprague Dawley rats were exposed to 2,3,4,6-tetrachlorophenol (TCP) for 5 days, 2 weeks, 4 weeks, or 13 weeks. TCP was administered by gavage at doses of 0, 10, 25, 50, 100, or 200 mg/kg/day. Endpoints evaluated included clinical observations, body weights, liver weights, serum chemistry, blood TCP, gross pathology, and liver histopathology. There were no TCP exposure-related clinical sign...
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The renal medulla plays an important role in cardiovascular regulation, through interactions with the autonomic nervous system. Hydronephrosis is characterized by substantial loss of renal medullary tissue. However, whether alterations in autonomic control of the heart are observed in this condition is unknown. Thus we assessed resting hemodynamics and baroreflex sensitivity (BRS) for control o...
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Methacrylonitrile (MeAN) is used in the preparation of plastics, elastomers, homoand copolymers and coatings (Windholz, 1983; Sax and Lewis, 1987) and as a chemical intermediate in the preparation of numerous organic chemicals (Windholz, 1983). MeAN is also used as a replacement for acrylonitrile in the manufacture of carbonated beverage containers (Cosidine, 1974) and is identified as a compon...
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ژورنال
عنوان ژورنال: EuPA Open Proteomics
سال: 2016
ISSN: 2212-9685
DOI: 10.1016/j.euprot.2016.03.017